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The XTerra® family of HPLC columns, based upon first generation hybrid particles, allows chromatographers to use high pH for drug discovery, method development and purification separations.

DMSO injection resistance of the rugged XTerra particle imparts long column lifetimes in high-throughput drug discovery applications

Wide pH range lets method development scientists operate at the pH necessary for optimal selectivity

High mass loading capacity lets isolation and purification scientists load up to 60x more material per injection

XTerra® columns combine the best properties of silica and polymers with the revolutionary patented* Hybrid Particle Technology, which replaces one out of every three silanols with a methyl group during synthesis. This hydrophobicity is distributed through the entire structure of the particle backbone, resulting in a rugged hybrid (inorganic/organic) particle that can be operated at:

• High speeds
• High temperatures
• High pH.

XTerra RP18 columns are general purpose, hybrid-based, reversed-phase C18 columns that incorporate Waters patented embedded polar group technology to improve peak shape performance for highly basic compounds. These first generation columns provide superior pH stability compared to a silica-based column.