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The ProPac SCX column line has expanded to include the next generation ProPac SCX-20 column. This column provides unequalled high resolution of protein variants.

ProPac SCX-10 and WCX-10 strong and weak cation-exchange columns are based on a nonporous core particle that results in highly-efficiency peaks and high-resolution separations of protein variants. A hydrophilic layer prevents unwanted secondary interactions. A grafted cation-exchange surface provides pH-based selectivity control and fast mass transfer for high-efficiency separation and moderate capacity.

• Characterization and quality control assessment of monoclonal antibodies and other proteins
• Unequalled resolution
• High-resolution separations with excellent sample recovery
• Unmatched column-to-column and lot-to-lot reproducibility
• Useful for characterization of related protein variants (e.g., deamidation and MAb lysine truncation variants)
• Highly-efficient peaks with excellent sample recovery
• Available in different dimensions and formats for flexibility in method development

The ProPac SCX-10 is a strong cation-exchange column with sulfonate functional groups, and the ProPac WCX-10 has a carboxylate functional group. Both are based on 10 µm nonporous, polymeric beads and coated with a proprietary hydrophilic layer.

All ProPac columns are manufactured and tested under the strictest specifications, resulting in unmatched column-to-column and lot-to-lot reproducibility. Dionex also offers these columns as lot-select packages containing three columns from a single lot or three columns from three different lots, to assist quality control scientists in method validation.