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760401.46
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NUCLEODUR C18 ISIS

by MACHEREY-NAGEL

NUCLEODUR® high purity silica phases for HPLC

Features

NUCLEODUR® is a fully synthetical type B silica (silica of 3rd generation) offering highly advanced physical properties:

  • totally spherical particle shape
  • outstanding surface microstructure
  • high pressure stability
  • low metal content

NUCLEODUR® as a state-of-the-art silica is the ideal base material for modern HPLC phases. It is the result of MACHEREY-NAGEL's pioneering research in chromatography for almost 50 years.
NUCLEODUR® with 1.8 µm particle size for increased separation efficiency

NUCLEODUR® C18 Isis - High purity silica phase for HPLC
Nonpolar crosslinked polymeric octadecyl modification
high steric selectivity · endcapped · 20 % C · USP L1

Properties
 Key features:

  • Exceptional steric selectivity
  • Outstanding surface deactivation
  • Suitable for LC/MS and HPLC at pH extremes (pH 1–10)

Technical characteristics:
C18 phase with special polymeric, crosslinked surface modification
pore size 110 Å; particle sizes 1.8 μm, 3 μm and 5 μm; carbon content 20 %
 Recommended application:
Steroids, (o,p,m-) substituted aromatics, fat-soluble vitamins

Application areas:
Aromatic compounds Pharmaceutical molecules Vitamins
Specification
Vendor MACHEREY-NAGEL Max Pressure 8700
Brand NUCLEODUR C18 ISIS Surface Area 340
Modifification Silica/C18 Carbon Load, % 20.0
Mode Reversed-Phase Endcapped Yes
Particle Size Operating Temperature 60
Length pH stability from 1.0
Internal Diameter pH stability to 10.0
Pore size 110
Similar columns Columns with same mode & modification — across all brands
VendorBrandModeModification Int. diam.LengthParticlesPoresPrice
Princeton Chromatography Inc. PrincetonSPHER OMNI C18-60 Reversed-Phase Silica/C18 10.0 mm 100 mm 10.0 μm 60 Å On request
Higgins Analytical HEAVY C18 Reversed-Phase Silica/C18 1.0 mm 100 mm 5.0 μm 100 Å On request
Teknokroma Mediterranea Sea18 Reversed-Phase Silica/C18 4.6 mm 30 mm 5.0 μm 100 Å On request
Sepax Technologies Sepax Bio 200 C18 Reversed-Phase Silica/C18 4.6 mm 250 mm 5.0 μm 200 Å On request
Phenomenex Clarity Oligo-MS Reversed-Phase Silica/C18 4.6 mm 100 mm 2.6 μm 100 Å On request
Phenomenex HyperClone Reversed-Phase Silica/C18 4.6 mm 300 mm 5.0 μm 120 Å On request
GL Sciences Inertsil ODS-3 Reversed-Phase Silica/C18 1.0 mm 33 mm 5.0 μm 100 Å On request
WATERS Atlantis T3 Reversed-Phase Silica/C18 3.0 mm 50 mm 5.0 μm 100 Å On request
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