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760405.2
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NUCLEODUR C18 ISIS

by MACHEREY-NAGEL

NUCLEODUR® high purity silica phases for HPLC

Features

NUCLEODUR® is a fully synthetical type B silica (silica of 3rd generation) offering highly advanced physical properties:

  • totally spherical particle shape
  • outstanding surface microstructure
  • high pressure stability
  • low metal content

NUCLEODUR® as a state-of-the-art silica is the ideal base material for modern HPLC phases. It is the result of MACHEREY-NAGEL's pioneering research in chromatography for almost 50 years.
NUCLEODUR® with 1.8 µm particle size for increased separation efficiency

NUCLEODUR® C18 Isis - High purity silica phase for HPLC
Nonpolar crosslinked polymeric octadecyl modification
high steric selectivity · endcapped · 20 % C · USP L1

Properties
 Key features:

  • Exceptional steric selectivity
  • Outstanding surface deactivation
  • Suitable for LC/MS and HPLC at pH extremes (pH 1–10)

Technical characteristics:
C18 phase with special polymeric, crosslinked surface modification
pore size 110 Å; particle sizes 1.8 μm, 3 μm and 5 μm; carbon content 20 %
 Recommended application:
Steroids, (o,p,m-) substituted aromatics, fat-soluble vitamins

Application areas:
Aromatic compounds Pharmaceutical molecules Vitamins
Specification
Vendor MACHEREY-NAGEL pH stability from 1.0
Brand NUCLEODUR C18 ISIS pH stability to 10.0
Modifification Silica/C18 Max Pressure 13050
Mode Reversed-Phase Surface Area 340
Particle Size Carbon Load, % 20.0
Length Endcapped Yes
Internal Diameter Operating Temperature 60
Pore size 110
Similar columns Columns with same mode & modification — across all brands
VendorBrandModeModification Int. diam.LengthParticlesPoresPrice
CERI L-column2 ODS (Non-sleeved) Reversed-Phase Silica/C18 0.1 mm 150 mm 3.0 μm 120 Å On request
BISCHOFF ProntoSIL 60-5-C18 H Reversed-Phase Silica/C18 4.6 mm 300 mm 5.0 μm 60 Å On request
CHEMINDIA CHEMSIL-BDS-C18 Reversed-Phase Silica/C18 3.9 mm 100 mm 3.0 μm 100 Å On request
SiliCYCLE SiliaChrom XT C18 Reversed-Phase Silica/C18 10.0 mm 250 mm 5.0 μm 150 Å On request
CHEMINDIA CHEMSIL-BDS-C18 Reversed-Phase Silica/C18 1.0 mm 50 mm 3.0 μm 100 Å On request
WATERS Spherisorb ODS2 Reversed-Phase Silica/C18 4.6 mm 50 mm 5.0 μm 80 Å On request
BISCHOFF ProntoSIL 60-10-C18 H Reversed-Phase Silica/C18 3.0 mm 125 mm 10.0 μm 60 Å On request
Agilent Technologies ZORBAX Extend-C18 Reversed-Phase Silica/C18 4.0 mm 250 mm 5.0 μm 80 Å On request
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