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760405.46
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NUCLEODUR C18 ISIS

by MACHEREY-NAGEL

NUCLEODUR® high purity silica phases for HPLC

Features

NUCLEODUR® is a fully synthetical type B silica (silica of 3rd generation) offering highly advanced physical properties:

  • totally spherical particle shape
  • outstanding surface microstructure
  • high pressure stability
  • low metal content

NUCLEODUR® as a state-of-the-art silica is the ideal base material for modern HPLC phases. It is the result of MACHEREY-NAGEL's pioneering research in chromatography for almost 50 years.
NUCLEODUR® with 1.8 µm particle size for increased separation efficiency

NUCLEODUR® C18 Isis - High purity silica phase for HPLC
Nonpolar crosslinked polymeric octadecyl modification
high steric selectivity · endcapped · 20 % C · USP L1

Properties
 Key features:

  • Exceptional steric selectivity
  • Outstanding surface deactivation
  • Suitable for LC/MS and HPLC at pH extremes (pH 1–10)

Technical characteristics:
C18 phase with special polymeric, crosslinked surface modification
pore size 110 Å; particle sizes 1.8 μm, 3 μm and 5 μm; carbon content 20 %
 Recommended application:
Steroids, (o,p,m-) substituted aromatics, fat-soluble vitamins

Application areas:
Aromatic compounds Pharmaceutical molecules Vitamins
Specification
Vendor MACHEREY-NAGEL pH stability from 1.0
Brand NUCLEODUR C18 ISIS pH stability to 10.0
Modifification Silica/C18 Max Pressure 8700
Mode Reversed-Phase Surface Area 340
Particle Size Carbon Load, % 20.0
Length Endcapped Yes
Internal Diameter Operating Temperature 60
Pore size 110
Similar columns Columns with same mode & modification — across all brands
VendorBrandModeModification Int. diam.LengthParticlesPoresPrice
Sepax Technologies Sepax BR 120 C18 Reversed-Phase Silica/C18 2.1 mm 150 mm 1.8 μm 120 Å On request
CHEMINDIA CHEMSIL-BDS-C18 Reversed-Phase Silica/C18 2.0 mm 50 mm 5.0 μm 100 Å On request
Thermo Fisher Scientific Hypesil GOLD Reversed-Phase Silica/C18 0.075 mm 100 mm 1.9 μm 175 Å On request
GRACE Vydac TP C18 Reversed-Phase Silica/C18 10.0 mm 150 mm 10.0 μm 300 Å On request
GRACE VisionHT C18 Basic Reversed-Phase Silica/C18 2.1 mm 20 mm 1.5 μm 120 Å On request
SGE Analytical Science ProteCol C18 G (Stainless Steel) Reversed-Phase Silica/C18 4.6 mm 100 mm 2.5 μm 120 Å On request
Welch Materials Topsil C18 Reversed-Phase Silica/C18 4.0 mm 30 mm 3.0 μm 150 Å On request
Higgins Analytical HAISIL HL C18 Reversed-Phase Silica/C18 2.1 mm 30 mm 5.0 μm 100 Å On request
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