760453.2

NUCLEODUR® high purity silica phases for HPLC

Features

NUCLEODUR® is a fully synthetical type B silica (silica of 3rd generation) offering highly advanced physical properties:

• totally spherical particle shape
• outstanding surface microstructure
• high pressure stability
• low metal content

NUCLEODUR® as a state-of-the-art silica is the ideal base material for modern HPLC phases. It is the result of MACHEREY-NAGEL's pioneering research in chromatography for almost 50 years.
NUCLEODUR® with 1.8 µm particle size for increased separation efficiency

NUCLEODUR® PFP
High purity silica phase for HPLC
Pentafluorophenyl-propyl modification,
multi-endcapped · 8 % C · USP L43

Properties
 Key features:

• Hydrophobic phase with alternative selectivity in comparison to classical C18 modifications
• Separation mechanism based on 4 retention mechanisms (polar interactions (H bonds), dipole-dipole interactions, π-π interactions, hydrophobic interactions)
• Suitable for LC/MS due to low bleeding characteristics

Technical characteristics:
Phase with pentafluorophenyl-propyl modification and multi-endcapping;
pore size 110 Å; particle sizes 3 µm and 5 µm;
carbon content 8 %; pH stability 1–9
 Recommended application:
Aromatic and unsaturated compounds, phenols, halogenated compounds, isomers,  polar compounds like pharmaceuticals, antibiotics; high retention of basic compounds