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763136.3

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763136.3
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NUCLEOSHELL RP 18

by MACHEREY-NAGEL

NUCLEOSHELL core-shell silica phases for HPLC  
 
Features

NUCLEOSHELL  Core-shell technology:

  • Solid core of silicon dioxide, homogeneous shell of porous silica
  • Highest efficiency compared to traditional totally porous materials
  • Particle size 2.7 µm (core 1.7 µm); lower back pressure also allows use on conventional LC systems


NUCLEOSHELL RP 18 -  Core-shell technology silica phase for HPLC
Octadecyl modification with multi-endcapping · 7.5 % C · USP L1

Properties
 
 Key features:

  • Based on core-shell particle technology for fast and efficient HPLC
  • Suitable for LC/MS and HPLC at pH extremes (pH 1–11)
  • Superior base deactivation, ideal for method development  

 Technical characteristics:
Octadecyl modification, multi-endcapped; pore size 90 Å, particle size 2.7 μm; carbon content 7.5 %
 Recommended application:
Overall sophisticated analytical separations, e.g., analgesics, antiinflammatory drugs, antidepressants; herbicides; phytopharmaceuticals; immunosuppressants

Application areas:
Pharmaceutical molecules
Specification
Vendor MACHEREY-NAGEL Max Pressure 8700
Brand NUCLEOSHELL RP 18 Surface Area N/A
Modifification Silica/C18 Carbon Load, % 7.5
Mode Reversed-Phase Endcapped Yes
Particle Size Operating Temperature 60
Length pH stability from 1.0
Internal Diameter pH stability to 11.0
Pore size 90
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ACE ACE C18-300 Reversed-Phase Silica/C18 2.1 mm 250 mm 5.0 μm 300 Å On request
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Axxiom Chromatography Axxiom C18 Reversed-Phase Silica/C18 4.6 mm 150 mm 5.0 μm — On request
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