SiliaChrom® Preparative HPLC Columns XT C18

The SiliaChrom XT C18 column is designed for application to be run at very high pH (up to 12,0) at room temperature but also suitable for low pH (down to 1,5). The other one, SiliaChrom XT C18 Fidelity, is used at high pH conditions with a higher thermal capacity. The only difference between SiliaChrom XT and SiliaChrom XT Fidelity is the way how the HPLC column is packed (proprietary) given more robustness at high pH and temperature.

The key is to have a hybrid particle or hybrid surface to reduce de solubility of the silica at high pH. In fact, the SiliaChrom XT is silica coated with a prepolymer of methyltriethoxysilane/tetraethoxysilane, followed by special thermal treatment to get a rigid surface that is less soluble than silica itself.

Main Characteristics

• Excellent durability at high pH
• Ideal for basic compounds
• High thermal stability
• Ideal for auto-purification (Prep. LC-MS)
• Double endcapped
• Best HPLC column for Metabolite Study